7O1Y

X-ray structure of furin in complex with the guanylhydrazone-based inhibitor 2 (mi307) soaked at 0.25 M NaCl

7O1Y の概要

• エントリーDOI: 10.2210/pdb7o1y/pdb
• 分子名称: Furin, [[(2E)-2-[[4-[(E)-[[azaniumylidene(azanyl)methyl]hydrazinylidene]methyl]phenyl]methylidene]hydrazinyl]-azanyl-methylidene]azanium, CALCIUM ION, ... (8 entities in total)
• 機能のキーワード: proprotein convertase, inhibitor, sars-cov-2, protease, complex, furin, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 53905.11

構造登録者

Dahms, S.O.,Brandstetter, H. (登録日: 2021-03-30, 公開日: 2021-09-01, 最終更新日: 2024-01-31)

• 主引用文献: Dahms, S.O.,Haider, T.,Klebe, G.,Steinmetzer, T.,Brandstetter, H.; OFF-State-Specific Inhibition of the Proprotein Convertase Furin.; Acs Chem.Biol., 16:1692-1700, 2021; PubMed: 34415722; DOI: 10.1021/acschembio.1c00411

実験手法

X-RAY DIFFRACTION (1.7 Å)