7O0M

Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023)

Summary for 7O0M

• Entry DOI: 10.2210/pdb7o0m/pdb
• Descriptor: N6-adenosine-methyltransferase catalytic subunit, N6-adenosine-methyltransferase non-catalytic subunit, 4-[4-[(4,4-dimethylpiperidin-1-yl)methyl]phenyl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ... (5 entities in total)
• Functional Keywords: mettl3, inhibitor, complex, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 62378.11

Authors

Bedi, R.K.,Dolbois, A.,Caflisch, A. (deposition date: 2021-03-26, release date: 2021-09-15, Last modification date: 2024-11-13)

• Primary citation: Bedi, R.K.,Dolbois, A.,Caflisch, A.; Crystal structure of the human METTL3-METTL14 complex bound to Compound 9 (ADO_AD_023); To Be Published,

Experimental method

X-RAY DIFFRACTION (2.39 Å)