7NZY
Crystal structure of human Casein Kinase I delta in complex with CGS-15943
Summary for 7NZY
Entry DOI | 10.2210/pdb7nzy/pdb |
Descriptor | Casein kinase I isoform delta, 9-chloranyl-2-(furan-2-yl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine, MALONATE ION, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, complex, atp-competitive, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 147762.29 |
Authors | Pichlo, C.,Baumann, U. (deposition date: 2021-03-24, release date: 2022-10-05, Last modification date: 2024-01-31) |
Primary citation | Wesseler, F.,Lohmann, S.,Riege, D.,Halver, J.,Roth, A.,Pichlo, C.,Weber, S.,Takamiya, M.,Muller, E.,Ketzel, J.,Flegel, J.,Gihring, A.,Rastegar, S.,Bertrand, J.,Baumann, U.,Knippschild, U.,Peifer, C.,Sievers, S.,Waldmann, H.,Schade, D. Phenotypic Discovery of Triazolo[1,5- c ]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. J.Med.Chem., 65:15263-15281, 2022 Cited by PubMed: 36346705DOI: 10.1021/acs.jmedchem.2c01199 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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