7NZV

14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-120

Summary for 7NZV

• Entry DOI: 10.2210/pdb7nzv/pdb
• Related: 6QHL
• Descriptor: 14-3-3 protein sigma, Transcription factor p65, 4-methanoyl-N-methyl-N-(oxan-4-yl)benzenesulfonamide, ... (5 entities in total)
• Functional Keywords: benzaldehyde, covalent fragment, p65, 1433, rela, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 28290.14

Authors

Wolter, M.,Ottmann, C. (deposition date: 2021-03-24, release date: 2021-06-09, Last modification date: 2024-01-31)

• Primary citation: Wolter, M.,Valenti, D.,Cossar, P.J.,Hristeva, S.,Levy, L.M.,Genski, T.,Hoffmann, T.,Brunsveld, L.,Tzalis, D.,Ottmann, C.; An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-kappa B-Utilizing a Reversible Covalent Tethering Approach.; J.Med.Chem., 64:8423-8436, 2021; PubMed: 34076416; DOI: 10.1021/acs.jmedchem.1c00401

Experimental method

X-RAY DIFFRACTION (1.4 Å)