7NXL
Structure of human cathepsin K in complex with the acrylamide inhibitor Gu3110
This is a non-PDB format compatible entry.
Summary for 7NXL
Entry DOI | 10.2210/pdb7nxl/pdb |
Descriptor | Cathepsin K, SULFATE ION, tert-butyl (1-((4-(dibenzylamino)-4-oxobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamate, ... (4 entities in total) |
Functional Keywords | hydrolase, complex, activity-based probe, acrylamide inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 24272.39 |
Authors | Busa, M.,Benysek, J.,Lemke, C.,Gutschow, M.,Mares, M. (deposition date: 2021-03-18, release date: 2021-09-08, Last modification date: 2024-05-01) |
Primary citation | Lemke, C.,Benysek, J.,Brajtenbach, D.,Breuer, C.,Jilkova, A.,Horn, M.,Busa, M.,Ulrychova, L.,Illies, A.,Kubatzky, K.F.,Bartz, U.,Mares, M.,Gutschow, M. An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity. J.Med.Chem., 64:13793-13806, 2021 Cited by PubMed: 34473502DOI: 10.1021/acs.jmedchem.1c01178 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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