7NWV

Structure of recombinant human beta-glucocerebrosidase in complex with BODIPY Tagged Cyclophellitol activity based probe

これはPDB形式変換不可エントリーです。

7NWV の概要

• エントリーDOI: 10.2210/pdb7nwv/pdb
• 分子名称: Lysosomal acid glucosylceramidase, 1-deoxy-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: beta-glucocerebrosidase, lysosomal glycoside hydrolase, gh30, hydrolase, cyclophellitol epoxide, activity based probe, complex
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117526.12

構造登録者

Rowland, R.J.,Davies, G.J. (登録日: 2021-03-17, 公開日: 2022-03-30, 最終更新日: 2024-01-31)

• 主引用文献: van der Gracht, D.,Rowland, R.J.,Roig-Zamboni, V.,Ferraz, M.J.,Louwerse, M.,Geurink, P.P.,Aerts, J.M.F.G.,Sulzenbacher, G.,Davies, G.J.,Overkleeft, H.S.,Artola, M.; Fluorescence polarisation activity-based protein profiling for the identification of deoxynojirimycin-type inhibitors selective for lysosomal retaining alpha- and beta-glucosidases.; Chem Sci, 14:9136-9144, 2023; PubMed: 37655021; DOI: 10.1039/d3sc01021j

実験手法

X-RAY DIFFRACTION (1.86 Å)