7NWK

Crystal structure of CDK9-Cyclin T1 bound by compound 6

7NWK の概要

• エントリーDOI: 10.2210/pdb7nwk/pdb
• 分子名称: Cyclin-dependent kinase 9, Cyclin-T1, N-((1R,3R)-3-(7-(4-fluoro-2-methoxyphenyl)-3H-imidazo[4,5-b]pyridin-2-yl)cyclopentyl)acetamide (3 entities in total)
• 機能のキーワード: inhibitor, kinase, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68364.78

構造登録者

Collie, G.W.,Ferguson, A.D. (登録日: 2021-03-16, 公開日: 2021-10-27, 最終更新日: 2024-05-01)

• 主引用文献: Barlaam, B.,De Savi, C.,Dishington, A.,Drew, L.,Ferguson, A.D.,Ferguson, D.,Gu, C.,Hande, S.,Hassall, L.,Hawkins, J.,Hird, A.W.,Holmes, J.,Lamb, M.L.,Lister, A.S.,McGuire, T.M.,Moore, J.E.,O'Connell, N.,Patel, A.,Pike, K.G.,Sarkar, U.,Shao, W.,Stead, D.,Varnes, J.G.,Vasbinder, M.M.,Wang, L.,Wu, L.,Xue, L.,Yang, B.,Yao, T.; Discovery of a Series of 7-Azaindoles as Potent and Highly Selective CDK9 Inhibitors for Transient Target Engagement.; J.Med.Chem., 64:15189-15213, 2021; PubMed: 34647738; DOI: 10.1021/acs.jmedchem.1c01249

実験手法

X-RAY DIFFRACTION (2.81 Å)