7NTN
The structure of RRM domain of human TRMT2A at 2 A resolution
Summary for 7NTN
Entry DOI | 10.2210/pdb7ntn/pdb |
Descriptor | tRNA (uracil-5-)-methyltransferase homolog A, SULFATE ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | trna binding, methyltransferase, trmt2a, polyq aggregation, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 9727.40 |
Authors | Davydova, E.,Janowski, R.,Witzenberger, M.,Niessing, D. (deposition date: 2021-03-10, release date: 2022-01-19, Last modification date: 2024-06-19) |
Primary citation | Margreiter, M.A.,Witzenberger, M.,Wasser, Y.,Davydova, E.,Janowski, R.,Metz, J.,Habib, P.,Sahnoun, S.E.M.,Sobisch, C.,Poma, B.,Palomino-Hernandez, O.,Wagner, M.,Carell, T.,Jon Shah, N.,Schulz, J.B.,Niessing, D.,Voigt, A.,Rossetti, G. Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. Comput Struct Biotechnol J, 20:443-458, 2022 Cited by PubMed: 35070167DOI: 10.1016/j.csbj.2021.12.029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.016 Å) |
Structure validation
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