7NTN

The structure of RRM domain of human TRMT2A at 2 A resolution

Summary for 7NTN

Entry DOI	10.2210/pdb7ntn/pdb
Descriptor	tRNA (uracil-5-)-methyltransferase homolog A, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	trna binding, methyltransferase, trmt2a, polyq aggregation, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	9727.40
Authors	Davydova, E.,Janowski, R.,Witzenberger, M.,Niessing, D. (deposition date: 2021-03-10, release date: 2022-01-19, Last modification date: 2024-06-19)
Primary citation	Margreiter, M.A.,Witzenberger, M.,Wasser, Y.,Davydova, E.,Janowski, R.,Metz, J.,Habib, P.,Sahnoun, S.E.M.,Sobisch, C.,Poma, B.,Palomino-Hernandez, O.,Wagner, M.,Carell, T.,Jon Shah, N.,Schulz, J.B.,Niessing, D.,Voigt, A.,Rossetti, G. Small-molecule modulators of TRMT2A decrease PolyQ aggregation and PolyQ-induced cell death. Comput Struct Biotechnol J, 20:443-458, 2022 Cited by PubMed: 35070167 DOI: 10.1016/j.csbj.2021.12.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.016 Å)

Structure validation