7NTH
Structure of TAK1 in complex with compound 54
Summary for 7NTH
Entry DOI | 10.2210/pdb7nth/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, GLYCEROL, DIMETHYL SULFOXIDE, ... (5 entities in total) |
Functional Keywords | kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 36413.84 |
Authors | Veerman, J.J.N.,Bruseker, Y.B.,Damen, E.,Heijne, E.H.,van Bruggen, W.,Hekking, K.F.W.,Winkel, R.,Hupp, C.D.,Keefe, A.D.,Liu, J.,Thomson, H.A.,Zhang, Y.,Cuozzo, J.W.,McRiner, A.J.,Mulvihill, M.J.,van Rijnsbergen, P.,Zech, B.,Renzetti, L.M.,Babiss, L.,Mueller, G. (deposition date: 2021-03-09, release date: 2021-04-07, Last modification date: 2024-06-19) |
Primary citation | Veerman, J.J.N.,Bruseker, Y.B.,Damen, E.,Heijne, E.H.,van Bruggen, W.,Hekking, K.F.W.,Winkel, R.,Hupp, C.D.,Keefe, A.D.,Liu, J.,Thomson, H.A.,Zhang, Y.,Cuozzo, J.W.,McRiner, A.J.,Mulvihill, M.J.,van Rijnsbergen, P.,Zech, B.,Renzetti, L.M.,Babiss, L.,Muller, G. Discovery of 2,4-1 H -Imidazole Carboxamides as Potent and Selective TAK1 Inhibitors. Acs Med.Chem.Lett., 12:555-562, 2021 Cited by PubMed: 33859795DOI: 10.1021/acsmedchemlett.0c00547 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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