7NTB

Crystal structure of human carbonic anhydrase with a benzophenone-derivative

7NTB の概要

• エントリーDOI: 10.2210/pdb7ntb/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, ~{N}-[[4-(phenylcarbonyl)phenyl]methyl]-4-sulfamoyl-benzamide, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor adduct, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29939.42

構造登録者

Di Fiore, A.,De Simone, G. (登録日: 2021-03-09, 公開日: 2022-03-16, 最終更新日: 2024-01-31)

• 主引用文献: Pagnozzi, D.,Pala, N.,Biosa, G.,Dallocchio, R.,Dessi, A.,Singh, P.K.,Rogolino, D.,Di Fiore, A.,De Simone, G.,Supuran, C.T.,Sechi, M.; Interaction Studies between Carbonic Anhydrase and a Sulfonamide Inhibitor by Experimental and Theoretical Approaches; Acs Med.Chem.Lett., 13:271-277, 2022; DOI: 10.1021/acsmedchemlett.1c00644

実験手法

X-RAY DIFFRACTION (1.7 Å)