7NRP

The crystal structure of a DNA:RNA hybrid duplex sequence CTTTTCTTTG

Summary for 7NRP

• Entry DOI: 10.2210/pdb7nrp/pdb
• Descriptor: RNA (5'-R(*CP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*G)-3'), CACODYLATE ION, ... (4 entities in total)
• Functional Keywords: amide-lna, duplex, dna:rna, unmodified, dna-rna hybrid
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 6384.03

Authors

Thorpe, C.,Hardwick, J.,McDonough, M.A.,Hall, J.P.,Baker, Y.R.,El-Sagheer, A.H.,Brown, T. (deposition date: 2021-03-04, release date: 2022-06-22, Last modification date: 2024-01-31)

• Primary citation: Baker, Y.R.,Thorpe, C.,Chen, J.,Poller, L.M.,Cox, L.,Kumar, P.,Lim, W.F.,Lie, L.,McClorey, G.,Epple, S.,Singleton, D.,McDonough, M.A.,Hardwick, J.S.,Christensen, K.E.,Wood, M.J.A.,Hall, J.P.,El-Sagheer, A.H.,Brown, T.; An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.; Nat Commun, 13:4036-4036, 2022; PubMed: 35821218; DOI: 10.1038/s41467-022-31636-2

Experimental method

X-RAY DIFFRACTION (2.67 Å)