7NPX

Thioredoxin glutathione reductase from Schistosoma mansoni in complex with 3-(3-Methoxyquinoxalin-2-yl)propanoic acid at 24 hours of soaking

7NPX の概要

• エントリーDOI: 10.2210/pdb7npx/pdb
• 分子名称: Thioredoxin glutathione reductase, FLAVIN-ADENINE DINUCLEOTIDE, 3-(3-methoxyquinoxalin-2-yl)propanoic acid, ... (7 entities in total)
• 機能のキーワード: fragment binding, redox enzyme, inhibitor, flavoreductase, protein binding
• 由来する生物種: Schistosoma mansoni (Blood fluke)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 132974.34

構造登録者

Fata, F.,Silvestri, I.,Williams, D.L.,Angelucci, F. (登録日: 2021-02-28, 公開日: 2021-05-19, 最終更新日: 2024-01-31)

• 主引用文献: Fata, F.,Silvestri, I.,Ardini, M.,Ippoliti, R.,Di Leandro, L.,Demitri, N.,Polentarutti, M.,Di Matteo, A.,Lyu, H.,Thatcher, G.R.J.,Petukhov, P.A.,Williams, D.L.,Angelucci, F.; Probing the Surface of a Parasite Drug Target Thioredoxin Glutathione Reductase Using Small Molecule Fragments.; Acs Infect Dis., 7:1932-1944, 2021; PubMed: 33950676; DOI: 10.1021/acsinfecdis.0c00909

実験手法

X-RAY DIFFRACTION (2.7 Å)