7NPH

Crystal structure of Mycobacterium tuberculosis ArgC in complex with 5-methoxy-1,3-benzoxazole-2-carboxylic acid

7NPH の概要

• エントリーDOI: 10.2210/pdb7nph/pdb
• 分子名称: N-acetyl-gamma-glutamyl-phosphate reductase, 5-methoxy-1,3-benzoxazole-2-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: argc, n-acetyl-gamma-glutamyl-phosphate reductase, nagpr, arginine biosynthesis, oxidoreductase
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 292170.57

構造登録者

Gupta, P.,Mendes, V.,Blundell, T.L. (登録日: 2021-02-26, 公開日: 2021-06-30, 最終更新日: 2024-01-31)

• 主引用文献: Gupta, P.,Thomas, S.E.,Zaidan, S.A.,Pasillas, M.A.,Cory-Wright, J.,Sebastian-Perez, V.,Burgess, A.,Cattermole, E.,Meghir, C.,Abell, C.,Coyne, A.G.,Jacobs, W.R.,Blundell, T.L.,Tiwari, S.,Mendes, V.; A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis; Comput Struct Biotechnol J, 19:3491-3506, 2021; DOI: 10.1016/j.csbj.2021.06.006

実験手法

X-RAY DIFFRACTION (2.57 Å)