7NOT

Crystal structure of Mycobacterium tuberculosis ArgC in complex with nicotinamide adenine dinucleotide phosphate (NADP+) and 5-Methoxy-3-indoleacetic acid

Summary for 7NOT

• Entry DOI: 10.2210/pdb7not/pdb
• Descriptor: N-acetyl-gamma-glutamyl-phosphate reductase, (5-methoxy-1H-indol-3-yl)acetic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• Functional Keywords: argc, n-acetyl-gamma-glutamyl-phosphate reductase, nagpr, arginine biosynthesis, oxidoreductase
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 8
• Total formula weight: 285492.62

Authors

Gupta, P.,Mendes, V.,Blundell, T.L. (deposition date: 2021-02-25, release date: 2021-06-30, Last modification date: 2024-01-31)

• Primary citation: Gupta, P.,Thomas, S.E.,Zaidan, S.A.,Pasillas, M.A.,Cory-Wright, J.,Sebastian-Perez, V.,Burgess, A.,Cattermole, E.,Meghir, C.,Abell, C.,Coyne, A.G.,Jacobs, W.R.,Blundell, T.L.,Tiwari, S.,Mendes, V.; A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis; Comput Struct Biotechnol J, 19:3491-3506, 2021; DOI: 10.1016/j.csbj.2021.06.006

Experimental method

X-RAY DIFFRACTION (2.54 Å)