7NMK

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound methylation product 1-methoxyquinolin-4(1H)-one

Summary for 7NMK

• Entry DOI: 10.2210/pdb7nmk/pdb
• Descriptor: 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, 1-methoxy-4-oxoquinoline, ... (6 entities in total)
• Functional Keywords: methyltransferase, hqno-detoxification, sam-dependent, rv0560c, transferase
• Biological source: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• Total number of polymer chains: 1
• Total formula weight: 27210.16

Authors

Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (deposition date: 2021-02-23, release date: 2021-09-22, Last modification date: 2024-01-31)

• Primary citation: Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S.; Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.; J.Struct.Biol., 213:107794-107794, 2021; PubMed: 34506908; DOI: 10.1016/j.jsb.2021.107794

Experimental method

X-RAY DIFFRACTION (1.204 Å)