7NIC
CryoEM structure of disease related M854K MDA5-dsRNA filament in complex with ADP-AlF4(minor class)
Summary for 7NIC
Entry DOI | 10.2210/pdb7nic/pdb |
EMDB information | 12288 12294 |
Descriptor | Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3'), ... (6 entities in total) |
Functional Keywords | protein-rna complex, helical filament, atpase, innate immune receptor, immune system, antiviral protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 126293.75 |
Authors | |
Primary citation | Yu, Q.,Herrero Del Valle, A.,Singh, R.,Modis, Y. MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12:6668-6668, 2021 Cited by PubMed: 34795277DOI: 10.1038/s41467-021-27062-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.3 Å) |
Structure validation
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