7NH8

Crystal structure of human carbonic anhydrase II with N-((1-(6-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-4-sulfamoylbenzamide

これはPDB形式変換不可エントリーです。

7NH8 の概要

• エントリーDOI: 10.2210/pdb7nh8/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, N-((1-(6-((3aR,7R,7aS)-7-hydroxy-2,2-dimethyltetrahydro-[1,3]dioxolo[4,5-c]pyridin-5(4H)-yl)hexyl)-1H-1,2,3-triazol-4-yl)methyl)-4-sulfamoylbenzamide, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase ii, inhibitor, sulfonamide, metalloenzyme, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29891.12

構造登録者

Angeli, A.,Ferraroni, M. (登録日: 2021-02-10, 公開日: 2022-02-23, 最終更新日: 2024-01-31)

• 主引用文献: Pratesi, D.,Sodini, A.,Matassini, C.,Cardona, F.,Angeli, A.,Carta, F.,Ferraroni, M.,Supuran, C.T.,Goti, A.; Synthesis of Azasugar-Sulfonamide conjugates and their Evaluation as Inhibitors of Carbonic Anhydrases: the Azasugar Approach to Selectivity; Eur.J.Org.Chem., 2021; DOI: 10.1002/ejoc.202100250

実験手法

X-RAY DIFFRACTION (1.369 Å)