7NGA
CryoEM structure of the MDA5-dsRNA filament in complex with ADP with 88-degree helical twist
Summary for 7NGA
Entry DOI | 10.2210/pdb7nga/pdb |
EMDB information | 11937 12092 |
Descriptor | RNA (5'-R(P*UP*CP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*AP*CP*G)-3'), RNA (5'-R(P*AP*CP*GP*UP*CP*AP*UP*GP*CP*GP*CP*AP*UP*GP*G)-3'), Interferon-induced helicase C domain-containing protein 1, ... (5 entities in total) |
Functional Keywords | protein-rna complex, helical filament, atpase, innate immune receptor, immune system, antiviral protein |
Biological source | Mus musculus (Mouse) More |
Total number of polymer chains | 3 |
Total formula weight | 126192.79 |
Authors | |
Primary citation | Yu, Q.,Herrero Del Valle, A.,Singh, R.,Modis, Y. MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA. Nat Commun, 12:6668-6668, 2021 Cited by PubMed: 34795277DOI: 10.1038/s41467-021-27062-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.9 Å) |
Structure validation
Download full validation report