7NEU
Inhibitor Complex with Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)
Summary for 7NEU
| Entry DOI | 10.2210/pdb7neu/pdb |
| Descriptor | Carboxypeptidase B2, (1R,3S)-3-(4-ammoniobutyl)-1-(4-fluoro-2-(1-methyl-1H-imidazol-5-yl)benzyl)-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, ZINC ION, ... (8 entities in total) |
| Functional Keywords | inhibitor, complex, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 47031.81 |
| Authors | Brown, D.G.,Schaffner, A.P.,Vuillard, L.M.,Gloanec, P.,Raimbauld, E. (deposition date: 2021-02-04, release date: 2021-04-07, Last modification date: 2021-04-21) |
| Primary citation | Schaffner, A.P.,Sansilvestri-Morel, P.,Despaux, N.,Ruano, E.,Persigand, T.,Rupin, A.,Mennecier, P.,Vallez, M.O.,Raimbaud, E.,Desos, P.,Gloanec, P. Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa). J.Med.Chem., 64:3897-3910, 2021 Cited by PubMed: 33764059DOI: 10.1021/acs.jmedchem.0c02072 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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