7NEU

Inhibitor Complex with Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)

7NEU の概要

• エントリーDOI: 10.2210/pdb7neu/pdb
• 分子名称: Carboxypeptidase B2, (1R,3S)-3-(4-ammoniobutyl)-1-(4-fluoro-2-(1-methyl-1H-imidazol-5-yl)benzyl)-1,4-azaphosphinan-1-ium-3-carboxylate 4,4-dioxide, ZINC ION, ... (8 entities in total)
• 機能のキーワード: inhibitor, complex, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47031.81

構造登録者

Brown, D.G.,Schaffner, A.P.,Vuillard, L.M.,Gloanec, P.,Raimbauld, E. (登録日: 2021-02-04, 公開日: 2021-04-07, 最終更新日: 2021-04-21)

• 主引用文献: Schaffner, A.P.,Sansilvestri-Morel, P.,Despaux, N.,Ruano, E.,Persigand, T.,Rupin, A.,Mennecier, P.,Vallez, M.O.,Raimbaud, E.,Desos, P.,Gloanec, P.; Phosphinanes and Azaphosphinanes as Potent and Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor (TAFIa).; J.Med.Chem., 64:3897-3910, 2021; PubMed: 33764059; DOI: 10.1021/acs.jmedchem.0c02072

実験手法

X-RAY DIFFRACTION (2.8 Å)