7NEL

ER-PRS*(+) (Y537S) in complex with estradiol and SRC-2 coactivator peptide

Summary for 7NEL

• Entry DOI: 10.2210/pdb7nel/pdb
• Related: 7NDO
• Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, ESTRADIOL, ... (8 entities in total)
• Functional Keywords: human estrogen receptor alpha, hera-lbd, estradiol, src-2, ligand binding domain, er, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 62079.18

Authors

Kriegel, M.,Muller, Y.A. (deposition date: 2021-02-04, release date: 2021-08-25, Last modification date: 2024-01-31)

• Primary citation: Kriegel, M.,Wiederanders, H.J.,Alkhashrom, S.,Eichler, J.,Muller, Y.A.; A PROSS-designed extensively mutated estrogen receptor alpha variant displays enhanced thermal stability while retaining native allosteric regulation and structure.; Sci Rep, 11:10509-10509, 2021; PubMed: 34006920; DOI: 10.1038/s41598-021-89785-1

Experimental method

X-RAY DIFFRACTION (1.45 Å)