7NEC
ROR(gamma)t ligand binding domain in complex with allosteric ligand FM217
Summary for 7NEC
Entry DOI | 10.2210/pdb7nec/pdb |
Descriptor | Nuclear receptor ROR-gamma, 4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-2-yl)-1,2-oxazol-4-yl]methoxy]benzoic acid (3 entities in total) |
Functional Keywords | nuclear receptor, retinoic acid receptor-related orphan receptor gamma t, inverse agonist, nuclear protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 29219.10 |
Authors | Somsen, B.A.,de Vries, R.M.J.M.,Meijer, F.A.,Brunsveld, L. (deposition date: 2021-02-03, release date: 2021-06-02, Last modification date: 2024-01-31) |
Primary citation | Meijer, F.A.,Saris, A.O.W.M.,Doveston, R.G.,Oerlemans, G.J.M.,de Vries, R.M.J.M.,Somsen, B.A.,Unger, A.,Klebl, B.,Ottmann, C.,Cossar, P.J.,Brunsveld, L. Structure-Activity Relationship Studies of Trisubstituted Isoxazoles as Selective Allosteric Ligands for the Retinoic-Acid-Receptor-Related Orphan Receptor gamma t. J.Med.Chem., 64:9238-9258, 2021 Cited by PubMed: 34008974DOI: 10.1021/acs.jmedchem.1c00475 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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