7NDM

Crystal structure of the heterocyclic toxin methyltransferase from Mycobacterium tuberculosis with bound substrate 4-hydroxyisoquinolin-1(2H)-one

7NDM の概要

• エントリーDOI: 10.2210/pdb7ndm/pdb
• 分子名称: Heterocyclic toxin methyltransferase (Rv0560c), S-ADENOSYL-L-HOMOCYSTEINE, 4-oxidanyl-2~{H}-isoquinolin-1-one, ... (6 entities in total)
• 機能のキーワード: methyltransferase, hqno-detoxification, sam-dependent, 1, 4-dihydroxyisoqunioline, transferase
• 由来する生物種: Mycobacterium tuberculosis H37Rv
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27137.07

構造登録者

Denkhaus, L.,Sartor, P.,Einsle, O.,Gerhardt, S.,Fetzner, S. (登録日: 2021-02-02, 公開日: 2021-09-22, 最終更新日: 2024-01-31)

• 主引用文献: Sartor, P.,Denkhaus, L.,Gerhardt, S.,Einsle, O.,Fetzner, S.; Structural basis of O-methylation of (2-heptyl-)1-hydroxyquinolin-4(1H)-one and related compounds by the heterocyclic toxin methyltransferase Rv0560c of Mycobacterium tuberculosis.; J.Struct.Biol., 213:107794-107794, 2021; PubMed: 34506908; DOI: 10.1016/j.jsb.2021.107794

実験手法

X-RAY DIFFRACTION (1.35 Å)