7NCA
Type 1A alpha-synuclein filament seeded in vitro by filaments purified from Multiple Systems Atrophy Case 2
Summary for 7NCA
Entry DOI | 10.2210/pdb7nca/pdb |
EMDB information | 12264 |
Descriptor | Alpha-synuclein (1 entity in total) |
Functional Keywords | amyloid, multiple system atrophy, neurodegeneration, alpha-synuclein, filament, protein fibril |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 12 |
Total formula weight | 173713.30 |
Authors | Lovestam, S.K.A.,Schweighauser, M.,Scheres, S.H.W. (deposition date: 2021-01-28, release date: 2021-02-24, Last modification date: 2024-05-01) |
Primary citation | Lovestam, S.,Schweighauser, M.,Matsubara, T.,Murayama, S.,Tomita, T.,Ando, T.,Hasegawa, K.,Yoshida, M.,Tarutani, A.,Hasegawa, M.,Goedert, M.,Scheres, S.H.W. Seeded assembly in vitro does not replicate the structures of alpha-synuclein filaments from multiple system atrophy. Febs Open Bio, 11:999-1013, 2021 Cited by PubMed: 33548114DOI: 10.1002/2211-5463.13110 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.47 Å) |
Structure validation
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