7NC4
Crystal structure of human carbonic anhydrase VII (hCA VII) in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.
Summary for 7NC4
Entry DOI | 10.2210/pdb7nc4/pdb |
Descriptor | Carbonic anhydrase 7, ZINC ION, 4-[4-(2-chlorophenyl)carbonylpiperazin-1-yl]carbonylbenzenesulfonamide, ... (5 entities in total) |
Functional Keywords | protein-inhibitor adduct, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31583.16 |
Authors | Di Fiore, A.,De Simone, G. (deposition date: 2021-01-28, release date: 2021-07-14, Last modification date: 2024-01-31) |
Primary citation | Mancuso, F.,Di Fiore, A.,De Luca, L.,Angeli, A.,De Simone, G.,Supuran, C.T.,Gitto, R. Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII. Bioorg.Med.Chem., 44:116279-116279, 2021 Cited by PubMed: 34216985DOI: 10.1016/j.bmc.2021.116279 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
Download full validation report