7NC4

Crystal structure of human carbonic anhydrase VII (hCA VII) in complex with a 4-(4-aroylpiperazine-1-carbonyl)benzenesulfonamide derivative.

7NC4 の概要

• エントリーDOI: 10.2210/pdb7nc4/pdb
• 分子名称: Carbonic anhydrase 7, ZINC ION, 4-[4-(2-chlorophenyl)carbonylpiperazin-1-yl]carbonylbenzenesulfonamide, ... (5 entities in total)
• 機能のキーワード: protein-inhibitor adduct, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31583.16

構造登録者

Di Fiore, A.,De Simone, G. (登録日: 2021-01-28, 公開日: 2021-07-14, 最終更新日: 2024-01-31)

• 主引用文献: Mancuso, F.,Di Fiore, A.,De Luca, L.,Angeli, A.,De Simone, G.,Supuran, C.T.,Gitto, R.; Design, synthesis and biochemical evaluation of novel carbonic anhydrase inhibitors triggered by structural knowledge on hCA VII.; Bioorg.Med.Chem., 44:116279-116279, 2021; PubMed: 34216985; DOI: 10.1016/j.bmc.2021.116279

実験手法

X-RAY DIFFRACTION (1.6 Å)