7NBP

Solution structure of DNA duplex containing a 7,8-dihydro-8-oxo-1,N6-ethenoadenine base modification that induces exclusively A->T transversions in Escherichia coli

7NBP の概要

• エントリーDOI: 10.2210/pdb7nbp/pdb
• NMR情報: BMRB: 34596
• 分子名称: DNA (5'-D(*GP*TP*AP*CP*(EDA)P*CP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*AP*GP*TP*AP*C)-3') (2 entities in total)
• 機能のキーワード: modified dna, dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 5503.67

構造登録者

Aralov, A.V.,Gubina, N.,Cabrero, C.,Tsvetkov, V.B.,Turaev, A.V.,Fedeles, B.I.,Croy, R.G.,Isaakova, E.A.,Melnik, D.,Dukova, S.,Khrulev, A.A.,Varizhuk, A.M.,Gonzalez, C.,Zatsepin, T.S.,Essigmann, J.M. (登録日: 2021-01-27, 公開日: 2022-03-02, 最終更新日: 2024-06-19)

• 主引用文献: Aralov, A.V.,Gubina, N.,Cabrero, C.,Tsvetkov, V.B.,Turaev, A.V.,Fedeles, B.I.,Croy, R.G.,Isaakova, E.A.,Melnik, D.,Dukova, S.,Ryazantsev, D.Y.,Khrulev, A.A.,Varizhuk, A.M.,Gonzalez, C.,Zatsepin, T.S.,Essigmann, J.M.; 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli.; Nucleic Acids Res., 50:3056-3069, 2022; PubMed: 35234900; DOI: 10.1093/nar/gkac148

実験手法

SOLUTION NMR