7NBM

Co-crystal structure of Human Nicotinamide N-methyltransferase (NNMT) with the bisubstrate-like inhibitor (33)

7NBM の概要

• エントリーDOI: 10.2210/pdb7nbm/pdb
• 関連するPDBエントリー: 7BKG 7BLE 7NJB
• 分子名称: Nicotinamide N-methyltransferase, (E)-3-((5,6-dihydro-2H,4H-thiazolo[5,4,3-ij]quinolin-2-ylidene)amino)-2-hydroxy-1-(4-(isoquinolin-5-yl)piperazin-1-yl)-2-methylpropan-1-one (3 entities in total)
• 機能のキーワード: methyl transferase, drug discovery, inhibitor complex, nicotinamide, metabolic disorders, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127814.60

構造登録者

Schreuder, H.A.,Liesum, A. (登録日: 2021-01-27, 公開日: 2021-03-17, 最終更新日: 2024-01-31)

• 主引用文献: Kannt, A.,Rajagopal, S.,Hallur, M.S.,Swamy, I.,Kristam, R.,Dhakshinamoorthy, S.,Czech, J.,Zech, G.,Schreuder, H.,Ruf, S.; Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.; Molecules, 26:-, 2021; PubMed: 33668468; DOI: 10.3390/molecules26040991

実験手法

X-RAY DIFFRACTION (2.691 Å)