7NAM

LRP6_E1 in complex with Lr-EET-3.5

Summary for 7NAM

Entry DOI	10.2210/pdb7nam/pdb
Descriptor	Low-density lipoprotein receptor-related protein 6, Trypsin inhibitor 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	lrp6, wnt signaling, cystine knot peptide, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	40789.32
Authors	Hansen, S.,Hannoush, R.N. (deposition date: 2021-06-21, release date: 2022-06-29, Last modification date: 2023-10-25)
Primary citation	Hansen, S.,Zhang, Y.,Hwang, S.,Nabhan, A.,Li, W.,Fuhrmann, J.,Kschonsak, Y.,Zhou, L.,Nile, A.H.,Gao, X.,Piskol, R.,de Sousa E Melo, F.,de Sauvage, F.J.,Hannoush, R.N. Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling. Proc.Natl.Acad.Sci.USA, 119:e2207327119-e2207327119, 2022 Cited by PubMed: 36343233 DOI: 10.1073/pnas.2207327119 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation