7NAM

LRP6_E1 in complex with Lr-EET-3.5

7NAM の概要

• エントリーDOI: 10.2210/pdb7nam/pdb
• 分子名称: Low-density lipoprotein receptor-related protein 6, Trypsin inhibitor 2, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: lrp6, wnt signaling, cystine knot peptide, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40789.32

構造登録者

Hansen, S.,Hannoush, R.N. (登録日: 2021-06-21, 公開日: 2022-06-29, 最終更新日: 2023-10-25)

• 主引用文献: Hansen, S.,Zhang, Y.,Hwang, S.,Nabhan, A.,Li, W.,Fuhrmann, J.,Kschonsak, Y.,Zhou, L.,Nile, A.H.,Gao, X.,Piskol, R.,de Sousa E Melo, F.,de Sauvage, F.J.,Hannoush, R.N.; Directed evolution identifies high-affinity cystine-knot peptide agonists and antagonists of Wnt/ beta-catenin signaling.; Proc.Natl.Acad.Sci.USA, 119:e2207327119-e2207327119, 2022; PubMed: 36343233; DOI: 10.1073/pnas.2207327119

実験手法

X-RAY DIFFRACTION (1.6 Å)