7NAK

Cryo-EM structure of activated human SARM1 in complex with NMN and 1AD (TIR:1AD)

Summary for 7NAK

Entry DOI	10.2210/pdb7nak/pdb
EMDB information	24272
Descriptor	NAD(+) hydrolase SARM1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(5-iodanylisoquinolin-2-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate (2 entities in total)
Functional Keywords	nadase, axon degeneration, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	618150.66
Authors	Kerry, P.S.,Nanson, J.D.,Adams, S.,Cunnea, K.,Bosanac, T.,Kobe, B.,Hughes, R.O.,Ve, T. (deposition date: 2021-06-21, release date: 2022-03-23, Last modification date: 2024-06-05)
Primary citation	Shi, Y.,Kerry, P.S.,Nanson, J.D.,Bosanac, T.,Sasaki, Y.,Krauss, R.,Saikot, F.K.,Adams, S.E.,Mosaiab, T.,Masic, V.,Mao, X.,Rose, F.,Vasquez, E.,Furrer, M.,Cunnea, K.,Brearley, A.,Gu, W.,Luo, Z.,Brillault, L.,Landsberg, M.J.,DiAntonio, A.,Kobe, B.,Milbrandt, J.,Hughes, R.O.,Ve, T. Structural basis of SARM1 activation, substrate recognition, and inhibition by small molecules. Mol.Cell, 82:1643-, 2022 Cited by PubMed: 35334231 DOI: 10.1016/j.molcel.2022.03.007 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.9 Å)

Structure validation