7NAB
Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165
Summary for 7NAB
Entry DOI | 10.2210/pdb7nab/pdb |
Descriptor | CV3-25 Fab Heavy Chain, CV3-25 Fab Light Chain, Spike protein S2, ... (6 entities in total) |
Functional Keywords | human neutralizing mab, mper-targeting, sars-cov-2, spike, viral protein-immune system complex, viral protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 101894.91 |
Authors | Chen, Y.,Tolbert, W.D.,Pazgier, M. (deposition date: 2021-06-21, release date: 2021-12-08, Last modification date: 2024-04-03) |
Primary citation | Li, W.,Chen, Y.,Prevost, J.,Ullah, I.,Lu, M.,Gong, S.Y.,Tauzin, A.,Gasser, R.,Vezina, D.,Anand, S.P.,Goyette, G.,Chaterjee, D.,Ding, S.,Tolbert, W.D.,Grunst, M.W.,Bo, Y.,Zhang, S.,Richard, J.,Zhou, F.,Huang, R.K.,Esser, L.,Zeher, A.,Cote, M.,Kumar, P.,Sodroski, J.,Xia, D.,Uchil, P.D.,Pazgier, M.,Finzi, A.,Mothes, W. Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern. Cell Rep, 38:110210-110210, 2022 Cited by PubMed: 34971573DOI: 10.1016/j.celrep.2021.110210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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