7NAB

Crystal structure of human neutralizing mAb CV3-25 binding to SARS-CoV-2 S MPER peptide 1140-1165

7NAB の概要

• エントリーDOI: 10.2210/pdb7nab/pdb
• 分子名称: CV3-25 Fab Heavy Chain, CV3-25 Fab Light Chain, Spike protein S2, ... (6 entities in total)
• 機能のキーワード: human neutralizing mab, mper-targeting, sars-cov-2, spike, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 101894.91

構造登録者

Chen, Y.,Tolbert, W.D.,Pazgier, M. (登録日: 2021-06-21, 公開日: 2021-12-08, 最終更新日: 2024-04-03)

• 主引用文献: Li, W.,Chen, Y.,Prevost, J.,Ullah, I.,Lu, M.,Gong, S.Y.,Tauzin, A.,Gasser, R.,Vezina, D.,Anand, S.P.,Goyette, G.,Chaterjee, D.,Ding, S.,Tolbert, W.D.,Grunst, M.W.,Bo, Y.,Zhang, S.,Richard, J.,Zhou, F.,Huang, R.K.,Esser, L.,Zeher, A.,Cote, M.,Kumar, P.,Sodroski, J.,Xia, D.,Uchil, P.D.,Pazgier, M.,Finzi, A.,Mothes, W.; Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.; Cell Rep, 38:110210-110210, 2022; PubMed: 34971573; DOI: 10.1016/j.celrep.2021.110210

実験手法

X-RAY DIFFRACTION (2.15 Å)