7N91

P70 S6K1 IN COMPLEX WITH MSC2317067A-1

7N91 の概要

• エントリーDOI: 10.2210/pdb7n91/pdb
• 分子名称: Ribosomal protein S6 kinase beta-1, 4-{[(1S)-1-(3-fluorophenyl)-2-(methylamino)ethyl]amino}quinazoline-8-carboxamide (2 entities in total)
• 機能のキーワード: kinase domain, inhibitor, transferase, transferase-inhibitor complex, transferase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 77771.25

構造登録者

Mochalkin, I. (登録日: 2021-06-16, 公開日: 2022-07-06, 最終更新日: 2023-10-18)

• 主引用文献: DeSelm, L.,Huck, B.,Lan, R.,Neagu, C.,Potnick, J.,Xiao, Y.,Chen, X.,Jones, R.,Richardson, T.E.,Heasley, B.H.,Haxell, T.,Moore, J.,Tian, H.,Georgi, K.,Rohdich, F.,Sutton, A.,Johnson, T.,Mochalkin, I.,Jackson, J.,Lin, J.,Crowley, L.,Machl, A.,Clark, A.,Wilker, E.,Sherer, B.,Goutopoulos, A.; Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.; J.Med.Chem., 64:14603-14619, 2021; PubMed: 34596404; DOI: 10.1021/acs.jmedchem.1c01087

実験手法

X-RAY DIFFRACTION (3 Å)