7N8M

PptT PAP(CoA) 8978B complex

7N8M の概要

• エントリーDOI: 10.2210/pdb7n8m/pdb
• 分子名称: 4'-phosphopantetheinyl transferase PptT, COENZYME A, N-(2,6-diethylphenyl)-N'-(N-methylcarbamimidoyl)urea, ... (7 entities in total)
• 機能のキーワード: inhibitor, structural genomics, psi-biology, tb structural genomics consortium, tbsgc, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 56263.92

構造登録者

Mosior, J.W.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (登録日: 2021-06-15, 公開日: 2022-02-02, 最終更新日: 2023-10-18)

• 主引用文献: Ottavi, S.,Scarry, S.M.,Mosior, J.,Ling, Y.,Roberts, J.,Singh, A.,Zhang, D.,Goullieux, L.,Roubert, C.,Bacque, E.,Lagiakos, H.R.,Vendome, J.,Moraca, F.,Li, K.,Perkowski, A.J.,Ramesh, R.,Bowler, M.M.,Tracy, W.,Feher, V.A.,Sacchettini, J.C.,Gold, B.S.,Nathan, C.F.,Aube, J.; In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.; J.Med.Chem., 65:1996-2022, 2022; PubMed: 35044775; DOI: 10.1021/acs.jmedchem.1c01565

実験手法

X-RAY DIFFRACTION (1.57 Å)