7N7X
Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution
This is a non-PDB format compatible entry.
Summary for 7N7X
Entry DOI | 10.2210/pdb7n7x/pdb |
Related | 2ANW 2ANY 5tjx |
Descriptor | Plasma kallikrein light chain, Orladeyo, PHOSPHATE ION, ... (4 entities in total) |
Functional Keywords | kallikrein, blood, plasma, plasma kallikrein-mediated edema, acute hereditary angioedema, hae, hmwk, hereditary angioedema, haw, bradykinin, fletcher factor, kininogenin, serine protease, edema, orladeyo, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 27326.90 |
Authors | Krishnan, R.,Yarlagadda, B.S.,Kotian, P.,Polach, K.J.,Zhang, W. (deposition date: 2021-06-11, release date: 2021-09-15, Last modification date: 2023-10-18) |
Primary citation | Kotian, P.L.,Wu, M.,Vadlakonda, S.,Chintareddy, V.,Lu, P.,Juarez, L.,Kellogg-Yelder, D.,Chen, X.,Muppa, S.,Chambers-Wilson, R.,Davis Parker, C.,Williams, J.,Polach, K.J.,Zhang, W.,Raman, K.,Babu, Y.S. Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE). J.Med.Chem., 64:12453-12468, 2021 Cited by PubMed: 34436898DOI: 10.1021/acs.jmedchem.1c00511 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.097 Å) |
Structure validation
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