7N7M
Crystal Structure of PI5P4KIIAlpha complex with BI-2536
Summary for 7N7M
Entry DOI | 10.2210/pdb7n7m/pdb |
Descriptor | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 43924.54 |
Authors | |
Primary citation | Chen, S.,Chandra Tjin, C.,Gao, X.,Xue, Y.,Jiao, H.,Zhang, R.,Wu, M.,He, Z.,Ellman, J.,Ha, Y. Pharmacological inhibition of PI5P4K alpha / beta disrupts cell energy metabolism and selectively kills p53-null tumor cells. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 34001596DOI: 10.1073/pnas.2002486118 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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