7N5H

Cryo-EM structure of broadly neutralizing antibody 2-36 in complex with prefusion SARS-CoV-2 spike glycoprotein

7N5H の概要

• エントリーDOI: 10.2210/pdb7n5h/pdb
• EMDBエントリー: 24190
• 分子名称: Spike glycoprotein, 2-36 Fab heavy chain, 2-36 Fab light chain, ... (5 entities in total)
• 機能のキーワード: sars-cov-2, viral spike, trimer, glycoprotein, neutralizing antibody fab, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); 詳細
• タンパク質・核酸の鎖数: 9
• 化学式量合計: 513329.87

構造登録者

Casner, R.G.,Cerutti, G.,Shapiro, L. (登録日: 2021-06-05, 公開日: 2021-11-03, 最終更新日: 2022-11-16)

• 主引用文献: Wang, P.,Casner, R.G.,Nair, M.S.,Yu, J.,Guo, Y.,Wang, M.,Chan, J.F.,Cerutti, G.,Iketani, S.,Liu, L.,Sheng, Z.,Chen, Z.,Yuen, K.Y.,Kwong, P.D.,Huang, Y.,Shapiro, L.,Ho, D.D.; A monoclonal antibody that neutralizes SARS-CoV-2 variants, SARS-CoV, and other sarbecoviruses.; Emerg Microbes Infect, 11:147-157, 2022; PubMed: 34836485; DOI: 10.1080/22221751.2021.2011623

実験手法

ELECTRON MICROSCOPY (3.24 Å)