7N4I
Crystal structure of SARS-CoV-2 receptor binding domain in complex with neutralizing human antibody WRAIR-2057.
7N4I の概要
エントリーDOI | 10.2210/pdb7n4i/pdb |
分子名称 | WRAIR-2057 Antibody Fab Heavy Chain, WRAIR-2057 Antibody Fab Light Chain, Spike protein S1, ... (6 entities in total) |
機能のキーワード | neutralizing antibody, sars-cov-2, wrair-2057, receptor binding domain, antiviral protein, viral protein-immune system complex, viral protein/immune system |
由来する生物種 | Homo sapiens (human) 詳細 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 71225.27 |
構造登録者 | |
主引用文献 | Dussupt, V.,Sankhala, R.S.,Mendez-Rivera, L.,Townsley, S.M.,Schmidt, F.,Wieczorek, L.,Lal, K.G.,Donofrio, G.C.,Tran, U.,Jackson, N.D.,Zaky, W.I.,Zemil, M.,Tritsch, S.R.,Chen, W.H.,Martinez, E.J.,Ahmed, A.,Choe, M.,Chang, W.C.,Hajduczki, A.,Jian, N.,Peterson, C.E.,Rees, P.A.,Rutkowska, M.,Slike, B.M.,Selverian, C.N.,Swafford, I.,Teng, I.T.,Thomas, P.V.,Zhou, T.,Smith, C.J.,Currier, J.R.,Kwong, P.D.,Rolland, M.,Davidson, E.,Doranz, B.J.,Mores, C.N.,Hatziioannou, T.,Reiley, W.W.,Bieniasz, P.D.,Paquin-Proulx, D.,Gromowski, G.D.,Polonis, V.R.,Michael, N.L.,Modjarrad, K.,Joyce, M.G.,Krebs, S.J. Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations. Nat.Immunol., 22:1503-1514, 2021 Cited by PubMed: 34716452DOI: 10.1038/s41590-021-01068-z 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.284 Å) |
構造検証レポート
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