7N3U
Crystal structure of human WEE1 kinase domain in complex with ZN-c3
Summary for 7N3U
Entry DOI | 10.2210/pdb7n3u/pdb |
Descriptor | Wee1-like protein kinase, 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one (3 entities in total) |
Functional Keywords | phosphotransferase, protein kinase-like, alpha and beta proteins (a+b), cell division, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32695.27 |
Authors | Lee, C.C. (deposition date: 2021-06-02, release date: 2021-09-01, Last modification date: 2023-10-18) |
Primary citation | Huang, P.Q.,Boren, B.C.,Hegde, S.G.,Liu, H.,Unni, A.K.,Abraham, S.,Hopkins, C.D.,Paliwal, S.,Samatar, A.A.,Li, J.,Bunker, K.D. Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer. J.Med.Chem., 64:13004-13024, 2021 Cited by PubMed: 34423975DOI: 10.1021/acs.jmedchem.1c01121 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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