7N3U

Crystal structure of human WEE1 kinase domain in complex with ZN-c3

7N3U の概要

• エントリーDOI: 10.2210/pdb7n3u/pdb
• 分子名称: Wee1-like protein kinase, 1-[(7R)-7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one (3 entities in total)
• 機能のキーワード: phosphotransferase, protein kinase-like, alpha and beta proteins (a+b), cell division, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 32695.27

構造登録者

Lee, C.C. (登録日: 2021-06-02, 公開日: 2021-09-01, 最終更新日: 2023-10-18)

• 主引用文献: Huang, P.Q.,Boren, B.C.,Hegde, S.G.,Liu, H.,Unni, A.K.,Abraham, S.,Hopkins, C.D.,Paliwal, S.,Samatar, A.A.,Li, J.,Bunker, K.D.; Discovery of ZN-c3, a Highly Potent and Selective Wee1 Inhibitor Undergoing Evaluation in Clinical Trials for the Treatment of Cancer.; J.Med.Chem., 64:13004-13024, 2021; PubMed: 34423975; DOI: 10.1021/acs.jmedchem.1c01121

実験手法

X-RAY DIFFRACTION (2.65 Å)