7N2M

Crystal structure of DNA polymerase alpha catalytic core in complex with dCTP and template/primer having T-C mismatch at the post-insertion site

Summary for 7N2M

• Entry DOI: 10.2210/pdb7n2m/pdb
• Related: 4qcl
• Descriptor: DNA polymerase alpha catalytic subunit, RNA (5'-R(*GP*CP*CP*UP*GP*GP*AP*GP*CP*GP*C)-3'), DNA (5'-D(*AP*T*AP*GP*TP*CP*GP*CP*TP*CP*CP*AP*GP*GP*C)-3'), ... (10 entities in total)
• Functional Keywords: dna replication, dna polymerase, t-c mismatch, rna primer, dna template, human protein, dna polymerase alpha, transferase-dna-rna complex, transferase/dna/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 114817.49

Authors

Tahirov, T.H.,Baranovskiy, A.G.,Babayeva, N.D. (deposition date: 2021-05-29, release date: 2022-04-20, Last modification date: 2023-10-18)

• Primary citation: Baranovskiy, A.G.,Babayeva, N.D.,Lisova, A.E.,Morstadt, L.M.,Tahirov, T.H.; Structural and functional insight into mismatch extension by human DNA polymerase alpha.; Proc.Natl.Acad.Sci.USA, 119:e2111744119-e2111744119, 2022; PubMed: 35467978; DOI: 10.1073/pnas.2111744119

Experimental method

X-RAY DIFFRACTION (2.9 Å)