7N18
Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by a Chiral Hydroxamic Acid
Summary for 7N18
Entry DOI | 10.2210/pdb7n18/pdb |
Descriptor | Botulinum neurotoxin type A, ZINC ION, (3R)-3-(4-chlorophenyl)-N,5-dihydroxypentanamide, ... (5 entities in total) |
Functional Keywords | botulinum protease, bont/a, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Clostridium botulinum |
Total number of polymer chains | 2 |
Total formula weight | 102549.05 |
Authors | Silvaggi, N.R.,Allen, K.N. (deposition date: 2021-05-27, release date: 2022-07-06, Last modification date: 2024-01-17) |
Primary citation | Turner, L.D.,Nielsen, A.L.,Lin, L.,Campedelli, A.J.,Silvaggi, N.R.,Chen, J.S.,Wakefield, A.E.,Allen, K.N.,Janda, K.D. Use of Crystallography and Molecular Modeling for the Inhibition of the Botulinum Neurotoxin A Protease. Acs Med.Chem.Lett., 12:1318-1324, 2021 Cited by PubMed: 34413962DOI: 10.1021/acsmedchemlett.1c00325 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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