7N0V

Complex of recombinant Bet v 1 with Fab fragment of REGN5715

7N0V の概要

• エントリーDOI: 10.2210/pdb7n0v/pdb
• 分子名称: REGN5715 Fab heavy chain, REGN5715 Fab light chain, Major pollen allergen Bet v 1-A (3 entities in total)
• 機能のキーワード: birch pollen, allergy, neutralizing antibody, immunotherapy, allergen
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68512.26

構造登録者

Franklin, M.C.,Romero Hernandez, A. (登録日: 2021-05-26, 公開日: 2021-08-11, 最終更新日: 2024-11-06)

主引用文献

Atanasio, A.,Franklin, M.C.,Kamat, V.,Hernandez, A.R.,Badithe, A.,Ben, L.H.,Jones, J.,Bautista, J.,Yancopoulos, G.D.,Olson, W.,Murphy, A.J.,Sleeman, M.A.,Orengo, J.M.
Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.
J.Allergy Clin.Immunol., 149:200-211, 2022

PubMed Abstract: Blocking the major cat allergen, Fel d 1, with mAbs was effective in preventing an acute cat allergic response.

PubMed: 34126155
DOI: 10.1016/j.jaci.2021.05.038

実験手法

X-RAY DIFFRACTION (3.71 Å)