7MYY
Crystal Structure of HIV-1 PRS17 with GRL-142
Summary for 7MYY
Entry DOI | 10.2210/pdb7myy/pdb |
Descriptor | Protease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, GLYCEROL, ... (5 entities in total) |
Functional Keywords | hiv-1 protease, multi drug resistant, hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22511.75 |
Authors | Agniswamy, J.,Weber, I.T. (deposition date: 2021-05-22, release date: 2021-07-28, Last modification date: 2023-10-18) |
Primary citation | Agniswamy, J.,Kneller, D.W.,Ghosh, A.K.,Weber, I.T. Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 . Biochem.Biophys.Res.Commun., 566:30-35, 2021 Cited by PubMed: 34111669DOI: 10.1016/j.bbrc.2021.05.094 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
Download full validation report