7MYY

Crystal Structure of HIV-1 PRS17 with GRL-142

7MYY の概要

• エントリーDOI: 10.2210/pdb7myy/pdb
• 分子名称: Protease, (3S,3aR,5R,7aS,8S)-hexahydro-4H-3,5-methanofuro[2,3-b]pyran-8-yl [(2S,3R)-4-[{[2-(cyclopropylamino)-1,3-benzothiazol-6-yl]sulfonyl}(2-methylpropyl)amino]-1-(3,5-difluorophenyl)-3-hydroxybutan-2-yl]carbamate, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: hiv-1 protease, multi drug resistant, hydrolase inhibitor complex, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22511.75

構造登録者

Agniswamy, J.,Weber, I.T. (登録日: 2021-05-22, 公開日: 2021-07-28, 最終更新日: 2023-10-18)

• 主引用文献: Agniswamy, J.,Kneller, D.W.,Ghosh, A.K.,Weber, I.T.; Novel HIV PR inhibitors with C4-substituted bis-THF and bis-fluoro-benzyl target the two active site mutations of highly drug resistant mutant PR S17 .; Biochem.Biophys.Res.Commun., 566:30-35, 2021; PubMed: 34111669; DOI: 10.1016/j.bbrc.2021.05.094

実験手法

X-RAY DIFFRACTION (1.5 Å)