7MYO

Cryo-EM structure of p110alpha in complex with p85alpha inhibited by BYL-719

Summary for 7MYO

• Entry DOI: 10.2210/pdb7myo/pdb
• EMDB information: 24082
• Descriptor: Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide (3 entities in total)
• Functional Keywords: phosphoinositide 3-kinase (pi3k), activation, inhibition, activity-dependent conformational changes, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 211887.25

Authors

Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.-W.,Vogt, P.K. (deposition date: 2021-05-21, release date: 2021-11-10, Last modification date: 2024-05-29)

• Primary citation: Liu, X.,Yang, S.,Hart, J.R.,Xu, Y.,Zou, X.,Zhang, H.,Zhou, Q.,Xia, T.,Zhang, Y.,Yang, D.,Wang, M.W.,Vogt, P.K.; Cryo-EM structures of PI3K alpha reveal conformational changes during inhibition and activation.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34725156; DOI: 10.1073/pnas.2109327118

Experimental method

ELECTRON MICROSCOPY (2.92 Å)