7MYJ

Structure of full length human AMPK (a2b1g1) in complex with a small molecule activator MSG011

7MYJ の概要

• エントリーDOI: 10.2210/pdb7myj/pdb
• 分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (6 entities in total)
• 機能のキーワード: activator, kinase, ampk, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 268660.49

構造登録者

Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Waters, N.J.,Yu, D.,Scott, J.W.,Parker, M.W.,Hoffman, N.J.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G. (登録日: 2021-05-21, 公開日: 2022-06-29, 最終更新日: 2023-10-18)

• 主引用文献: Ovens, A.J.,Gee, Y.S.,Ling, N.X.Y.,Yu, D.,Hardee, J.P.,Chung, J.D.,Ngoei, K.R.W.,Waters, N.J.,Hoffman, N.J.,Scott, J.W.,Loh, K.,Spengler, K.,Heller, R.,Parker, M.W.,Lynch, G.S.,Huang, F.,Galic, S.,Kemp, B.E.,Baell, J.B.,Oakhill, J.S.,Langendorf, C.G.; Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator.; Biochem.J., 479:1181-1204, 2022; PubMed: 35552369; DOI: 10.1042/BCJ20220067

実験手法

X-RAY DIFFRACTION (2.95 Å)