7MXX

Crystal structure of human exonuclease 1 Exo1 (R92A) in complex with 5' flap DNA (uf4)

Summary for 7MXX

• Entry DOI: 10.2210/pdb7mxx/pdb
• Descriptor: Exonuclease 1, DNA (5'-D(*CP*GP*CP*TP*AP*GP*TP*GP*AP*C)-3'), DNA (5'-D(P*TP*CP*TP*CP*GP*TP*CP*AP*CP*TP*AP*GP*CP*G)-3'), ... (6 entities in total)
• Functional Keywords: human exonuclease 1 complex with dna, hydrolase, hydrolase-dna complex, hydrolase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 48221.16

Authors

Shi, Y.,Beese, L.S. (deposition date: 2021-05-19, release date: 2023-05-10, Last modification date: 2023-10-25)

• Primary citation: Shi, Y.,Hellinga, H.W.,Beese, L.S.; Structures of reaction intermediates reveal transient Mg2+-binding events that dynamically coordinate Human Exonuclease I activities; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.85 Å)